Braverman, E, Smith, R., Smayda, R, and Blum, K. Modification of P300 amplitude and other electrophysiological parameters of drug abuse by cranial electrical stimulation. Current Therapeutic Research. 48(4):586-596, 1990.
P300 waves have a reduced amplitude in many alcoholics, which does not revert to normal, even after continued abstinence. 13 alcohol and/or drug abusers and 2 staff controls were selected as they entered the clinic for a computerized EEG. All were given 40 minutes of CES between pre and post EEG. There were no significant changes in the controls.
Following the CES the patient’s P300 amplitude increased significantly (P<.05). The time went from a pre-treatment of 308 to 317 msec post-treatment. The amplitude (dV) went from pre-treatment of 7.0 to 9.9 post-treatment. Also there were significant positive shifts in alpha, delta, theta and beta spectra in patients who were abnormal in one or more of these areas prior to CES treatment.
It was concluded that CES might be a significant non-drug treatment for the underlying electrophysiological disorder of the drug abuser, because the normalization of these electrophysiological parameters are characteristic of pharmaceutical treatment.